Amicus Therapeutics, the Solution to Rare Diseases

Amicus Therapeutics is an American biopharmaceutical company based in New Jersey. It became a public company in 2007 and was funded by a variety venture capital companies including Enterprise Associates, Canaan Partners and Radius Ventures.

 

Main Focus of Amicus Therapeutics

 

The company mainly focuses on rare and orphan diseases. They offer medicine and unique technologies in the development of patients suffering from devastating and rare diseases such as the lysosomal storage disorder, Fabry disease, epidermolysis bullosa (EB); a genetic connective skin disorder, and Pompe diseases. The company’s lead upcoming product is Migalastat, a personalized drug that is in late-stage development to treat people with Fabry disease based on person’s genetic diagnosis.

 

Another candidate in the late stage development is SD-101, a possible first-to- market therapy for epidermolysis bullosa (EB). The company is also trying to advance its biologics and the Chaperone-Advanced Replacement Therapy, a platform advancement to invent Novel Enzyme Replacement Therapy products, for Pompe disease, Fabry diseases, and other various lysosomal storage disorders. The therapeutics frontline program is ATB200/AT2221, a uniquely Pompe disease enzyme replacement therapy, which is administered together with a pharmacological chaperone.

 

The Developmental Journey of Amicus Therapeutics

 

Amicus Therapeutics did not have a manufacturing capability and only relied on contract manufacturing alone. Luckily, the company expanded from New Jersey to another site in San Diego in 2008. Amicus then acquired competitor Callidus Biopharma, hence obtaining essential materials and advanced property for the Enzyme Replacement Therapy treatment of pompe disease. As of February 2014, Amicus Therapeutics still had no marketed products. Its most advanced potential product was migalastat (ReleaseFact). Between 2010 and 2013 the company collaborated with JCR Pharmaceutical and GlaxoSmithKline to research on formulation with recombinant alpha-galactosidase. Later in 2015 September, Amicus acquired Scioderm for around 947 million dollars in cash and stock.

 

Amicus Activities outside America

 

The company is committed to the Fabry community across the world and has recently seen approval of its migalastat by Health Canada for treatment of Fabry diseases in the country (https://www.google.com/finance?cid=706165). Amicus Therapeutics also attended and sponsored the Thirteenth International Congress of inborn metabolism errors, in Rio de Janeiro Brazil, to adopt the research of genetically passed metabolic disorders and related topics. The company’s CEO John Crowley was nominated in the 2017 PharmaVoicelist for his ground-breaking development of rare disease drugs.

 

Rubica Improves Personal Cyber Security

The relevance of personal cyber security has increased due to the growing number of cyber related threats. The proliferation of cyber attacks has led to damages to firms, governments, and individuals. Recently, a huge organization known as WannaCry suffered a significant cyber crime in May 2017. The company has inscribed a ransom that summed up to approximate 300,000 computers and digital software in more than 150 nations. However, due to the subjection of cyber crimes to anyone, I am a victim of cyber attack.

 

From the 2013-2015 periods, the number of cyber attacks quadrupled to almost $500 billion. According to a survey conducted by Global State of Information Security, personal cyber security can be enhanced by transforming business ecosystems to digital standards. Statistics report that own cyber security is an area that requires commitment. More firms, government departments, and organizations are adopting different mechanisms to cub cyber attack. Ventures in cyber security indicate that if the problem is not handled, cyber attack’s cost will rise to $6 trillion yearly. The damages posed include intellectual property theft, fraud, embezzlement and hacking of systems and data.

 

Besides normal individuals being affected, politicians are also subjected to the attacks. During President Obama’s reign, Obama proposed a budget of $19 million for the cyber security industry. In May 2017, the United States of America President, Donald Trump, commissioned an executive order aiming at improving personal cyber safety in the nation. The act was specifically geared towards enhancing security in information technology national networks and the systems of infrastructure.

 

Rubica provides the solutions to cyber attacks. Rubica is made up of a team of experts who provide digital security services. Rubica is easy to use in instances of cyber crime. It usually carries its operations in the background, giving an alert when the action is required. With Rubica, you will gain confidence regarding your online privacy and safety. Hackers will no longer intimidate online users due to the availability of sophisticated Rubica services (https://rubica.com/why-rubica/). Rubica does away with the complexity that comes along with personal cyber security. For ease of access and help when hacked, get the Rubica application to your tablets and smartphones. Tracking any sought of cyber attackers will be convenient.

Osteoarthritis Management Schedule From Osteo Relief Institute

Osteoarthritis is the most common type of arthritis and is characterized by causing cartilage degeneration and hence the name degenerative joint disease. After the cartilage breaks down and wears off, the joint bones start rubbing against each other. Over time, they lose their strength causing chronic pains. Dr. Matthew CiRullo of Family Medicine assures that although there is no cure for the condition, there is medication for making the pain bearable.

About Osteo Relief Institute

 

Osteo Relief Institute was founded in 2012 in New Jersey with the aim of helping patients suffering from osteoarthritis. The institute uses state of the art equipment to help their patients in relieving pain caused by arthritis. In addition to the equipment, they have highly qualified staff taking care of the patients.

 

Among the services offered at Osteo Relief Clinic include; screening, non-surgical treatment, guided knee injections, improving knee mobility, and inflammation and pain relief (HealthGrades). All these services are provided under the right plans to ensure you are comfortable.

 

In addition, Medicare covers the services offered any Osteo Relief Institute for all those patients who qualify for the plan. You are provided with the treatment procedure and all requirements during the risk-free screening.

 

According to Osteo Relief Institute, there are three management options for arthritis; daily routine habits such as proper diet, exercises, and medial options. They go concurrently for better results. Follow this routine for self-management.

 

Daily Routine

  • Perform gentle stretching exercises before bed to lessen stiffness in the morning.
  • Avoid staying in a fixed position for long and instead stand and walk around after every one hour.
  • Avoid overusing a joint as that can increase the pain.
  • Maintain the right body weight as excess weight increases the risks of getting osteoarthritis
  • Quit smoking as it damages connective tissues.
  • Do everything that is in your comfort zone instead of overburdening yourself.

Eli Gershkovitch’s Steamworks Is Competing With Mass-Market Beer Producers

Over the years, mass-market domestic beer dominated the industry. However, new companies are changing the game. The old era where the empires featured on Superbowl commercials has been fading out slowly. The new entrant in the beer market is the craft beer. This golden-age beer is pushed by huge demands from the millennials who prefers it to the mass-market domestic beer. The market shift has adversely affected the market share and popularity of mega-companies like Dubweiser and Miller Brewing Company. Presently, microbreweries are dominating the market. New entrants are generating huge revenues owing to an increase in the consumer base.

One of the companies that are making top-selling craft beer is Steamworks. The company sells a wide range of beer. Across the Canada and in the United States, Millennials love these brands. The company has achieved much success under the visionary leadership of Eli Gershkovitch. The master brewer serves as the company’s CEO. The executive has played a pivotal role in revolutionizing the industry. Eli Gershkovitch is using an unconventional approach to build Steamworks’ craft beer empire. Instead of the proud attitude used by many Fortune 500 companies, the chief executive officer uses a calm attitude, which is typical of the working-class men. He is casual and loves freedom. These values have helped him to conquer the competitive beer industry, as he builds his own brewing empire.

Despite his calm personality, Eli Gershkovitch is a master of business. He is driven by his motto of “grow to meet demand or it will shrink to meet you.” This motto is supported by economics from across the globe. In the last century, it was tested several times. According to the master brewer, the theory indicates that robust companies will grow and surpass stagnant companies, thus switching the market towards in his favor. In Canada, the number of companies that are venturing into the brewing industry is at an all-time high. According to industry data, most of these companies have started their operations in Ontario and other densely populated regions. Although most of these breweries tend to fail, a good portion of them curves a share for themselves (MontrealGazette). Eli Gershkovitch contends that the emergence of these corporations has continued to eat into the market share of the mass-market beer companies.

Eli Gershkovitch founded Steamworks in his pub in 1995. Over the years, he has grown the pub from 184 seats to 754 seats. Its success has seen many tourists flock the pub to have a taste of its popular beer brands. Eli Gershkovitch posits that the locals are regular clients at his pub. In addition, Eli is a professional lawyer and pilot.

More at http://www.westender.com/eat-drink/steamworks-is-much-more-than-a-brew-pub-1.879352

Dr. Mark Holterman – Volunteering with IPSAC-VN

Dr. Mark Holterman, a refined medical scientist, professional, and instructor, parts his opportunity between such duties as an educator giving services at the University of Illinois and as Chief Executive Officer at Mariam Global Health. Committed to assisting patients in an assortment of ways, Mark Holterman, MD, provides support to such magnanimous associations (https://www.crunchbase.com/person/dr-mark-holterman#/entity).

To keep helping human services experts in Vietnam enhance access to pediatric surgical care and add their ability to that kind of care, IPSAC-VN depends on the help of volunteers and donors. Volunteers give the most hands-on help of the association by offering patient care, lecturing, training, and surgery at subsidiary medicinal schools and health centers in Vietnam (Twitter). All volunteers need to have a visa and travel permit that is legitimate for no less than a half year after the trip date. Notwithstanding that information, therapeutic volunteers must furnish the association with a duplicate of their expert permit and CV.

When volunteers are acknowledged, IPSAC-VN proposes that they buy travel pharmaceutical protection and prescribe that they go to their specific goal no less than two days before they are set to begin their volunteering. Debriefing of the team is held before the begin date and after the ending date, and volunteers are in charge of travel, inn, and other costs once in Vietnam.

A pediatric specialist, Dr. Mark Holterman has filled in as an individual from the general surgical group at Children’s Hospital, OSF Healthcare since 2011. More so, he is an educator in the Pediatric Surgery division at the University Of Illinois College Of Peoria Medicine. Dr. Mark Holterman keeps up a solid enthusiasm for the advancement of cell-based treatments. Dr. Mark Holterman received medicine & immunology degree from the University of Virginia. He is also part of the various professional firms including the ADA – American Diabetes Association.

 

Dr. Mark Holterman exercised pediatric surgery and has researched on regenerative medicine for various years. He spends time in medical research and teaching surgery with the University of Illinois. Dr. Mark Holterman also provides surgical patients pediatric care at OSF St. Francis Medical Center. As demonstrated by his field success, Dr. Mark Holterman has acquired various awards from well-known organizations all over the world.

The Intriguing Thoughts And Enlightening Career Of Glen Wakeman

Glen Wakeman is often asked for advice due to his success in his career. He has revolutionized business, shown the true spirit of an entrepreneur, developed startup companies, created new methodologies, earned a BS in Economics, an MBA in Finance, and worked for numerous, prestigious companies. He is focused, and driven in business, with an established methodology, and strategies. The leadership, passion, and advice he has provided regarding the global marketplace has been accurate, and well received.

LaunchPad Holdings was an idea Glen Wakeman had to combine money with ideas. He realized the failures of numerous startups were due to not enough structure to encompass the ideas. This led to his creation of a platform to make establishing a plan for building these businesses more intuitive, and simpler. He divides the responsibilities with his partners, then begins researching the necessary elements. By the time his day is over, he celebrates with tea, coffee, or sometimes a margarita.

Glen Wakeman is thrilled with machines providing data for businesses problems. He believes machine learning can improve the quality, and efficiency of a business. This helps him in the creation of new ideas, provides organization for his thoughts, and helps him turn them into reality. A lot of his motivation comes when he explains his ideas to others. He is endlessly curious, an innovative thinker, and wants to understand the best way to make important changes.

Glen Wakeman once worked for an automobile parts factory cleaning bathroom (AffiliateDork). Although the job involved a lot of sweat, it paid for him to attend college. The job additionally drove home the lesson nothing should be taken for granted. He has learned to treasure his friends, although he wishes he had kept better records of many of them. He has reestablished a lot of lost connections through social media. These connections are the representation of the differences between failing, or succeeding to Glen Wakeman.

Glen Wakeman was impressed with the book The Art of War. He feels the strategy involved in the writing makes the book an all-time classic. The book taught him invaluable lessons regarding teamwork, preparation, and discipline.

Russian Meddling Made Easier By 2010 Supreme Court Ruling, Grassroots Anti-Corruption PAC Says

A “Rigged Political System On Steroids.”

That’s how the president of a new anti-corruption political action committee described the U.S. election system in wake of alarming revelations that Russian agents spent enormous sums of money to sway the 2016 elections.

Tiffany Muller is President of End Citizens United, a PAC that formed in 2015 with the goal of overturning the notorious 2010 Supreme Court ruling that came to be known as Citizens United. Muller said recent evidence that Russian Internet troll farms were buying up huge numbers of social media ads using fake accounts on Facebook and Twitter is yet another symptom of a campaign contribution process that has lost all transparency and credibility.

What’s more, Muller said the Republican party is simply unwilling to do anything about the hijacking of the American political system. That’s because they are addicted to big campaign contributions from sources that don’t have to reveal who or what they are – even if they are from a hostile foreign power.

End Citizens United (ECU) was formed as a PAC in 2015. As its name implies, the group’s goal is to someday overturn the 2010 Supreme Court ruling which unleashed disaster on the U.S. election process. ECU began fundraising in 2015 and raised a robust $25 million ahead of the 2016 election cycle.

Just about all of those donations were in tiny amounts – and average of just over $14 each – which proves that the goal of the ECU to get big money out of politics has powerful support among rank-and-file American voters.

The small donations continue to roll in – ECU officials say they are on track to beat the previous goal of $25 million by $10 million – or about $35 million for the coming 2018 midterm elections.

Muller said that no one should be under any doubt that allowing unlimited dark money from mega-corporations and billionaires has led to an alarming level of corruption. All this dark money floating around only makes it easier for foreign governments to inject cash into American elections, even though it is illegal to accept foreign funds for U.S. political campaigns. The 2010 Supreme Court ruling made it enormously more difficult to trace where any campaign contributions are coming from.

One of ECU’s strategies is to get as many Democrats elected as possible in 2018. A primary goal is to flip the House of Representatives from Republican to Democrat control. Democrats in general are hostile to what the 2010 Citizens United ruling made possible, while Republicans generally favor maintaining the dark money system.

Muller and other hope Democratic control will make it easier to eventually push through a Constitutional Amendment that would overturn the Citizens United “disaster.”

Learn more about End Citizens United: https://actionnetwork.org/groups/end-citizens-united

The Illegal Actions Of Joe Arpaio Lead To The Establishment Of The Frontera Fund

Sheriff Joe Arpaio has been a leading figure in the rise of anti-Hispanic rhetoric seen across the U.S. in the 2014 and 2016 election cycles. The former Maricopa County Sheriff became a regular figure in the conservative media where he was known for describing himself as the toughest cop in the U.S.; the problem for the people of Maricopa County, Arizona was the abuses of power the man known for racially profiling many members of the Hispanic community in Arizona. It was not only Hispanic individuals who were targeted by the sheriff but also journalists including Michael Lacey and Jim Larkin.

 

The Frontera Fund was established by Michael Lacey and Jim Larkin after they were illegally arrested and imprisoned by Sheriff Joe Arpaio in response to their publication of a story about the use of an illegal Supreme Court warrant by the law enforcement agency in Arizona’s Maricopa County. Legal officials in Maricopa County came together to ask for illegally obtained information about the employees and owners of the Phoenix New Times along with the identities and IP addresses of subscribers to the newspaper.

 

The main reasons for the actions of Sheriff Arpaio were his need to strike back against those he felt were attacking his action and personal integrity. Under the leadership of Michael Lacey and Jim Larkin, the Phoenix New Times ran a series of stories detailing the many waves of abuse of power committed by Sheriff Arpaio and his employees at Maricopa Sheriff’s department; among the abuses detailed by Larkin and Lacey were those surrounded conditions in the jails operated under the leadership of the Sheriff and his deputies which many found to be a health hazard. The publication of a story detailing the financial mismanagement of the Maricopa County Sheriffs Department was a major event in Arizona and led to the warrant being illegally issued by the Supreme Court.

 

Michael Lacey and Jim Larkin wrote a story detailing the illegal practices of the Supreme Court warrant issued on behalf of Joe Arpaio against Larkin and Lacey. The journalists were arrested in the middle of the night with unmarked vehicles and taken to different jails; arrested on unfair and illegal charges, Larkin and Lacey used the $3.75 million settlement they received for their unfair arrest to establish The Frontera Fund assisting members of the Hispanic community of Arizona racially profiled and targeted under the tenure of Arpaio as Sheriff of Maricopa County.

 

How Fabletics has built an outstanding Reputation in the E-Commerce Sector

Fabletics has been among the United States’ leading athleisure wear companies for the past four years that it has been in business. TechStyle partnered with Kate Hudson in establishing the firm in 2013, and it has currently attracted millions of clients. Fabletics is now in a position to compete with old e-commerce companies such as the Amazon. The firm has been capitalizing on the power of the crowdsourced reviews to offer top-notch activewear products to women across the United States. It has managed to make over $235 million from selling products, and its value also increases by more than 35 percent every year.

 

The power of the client reviews has enabled Fabletics to become one of the most successful e-commerce companies. The business sells most of its products online through a subscription plan that has more than one million loyal customers. Fabletics has become successful due to the robust relationships that it has developed with its customers. It has made sure that all products and services satisfy the needs of its clients, and this has enabled it to be offered positive reviews. The websites of the most successful e-commerce enterprises allow customers to write reviews about products that they have used. The comments are beneficial to other consumers since they inform them on the quality of goods. Many people tend to be attracted to buy products from brands that have an excellent reputation.

 

According to recent studies, a company’s crowdsourced reviews have a great impact on the sales that it makes. More than 80 percent of internet users trust the online comments that have been written by consumers. They consider them as personal recommendations and believe in them more than the traditional advertisements. The positive reviews that Fabletics gets from people who have used its products has enabled to retain over 85 percent of its customers. Consumers who have used its products also refer new clients to the company. The athleisure wear enterprise has been using the feedback that it gets from the customers to make its goods and services better. According to Kate Hudson, Fabletics has penetrated the online fashion market due to its determination to leverage the power of empathy, data, and technology.

 

Most of the world’s leading search engines have rated Fabletics well, and this makes it appear on the first page when it is looked up by clients. Consumers are also referred to the company whenever they search for anything about athleisure wear. Information that is offered on leading review websites portrays Fabletics as a reliable company that is committed to providing the best products to the clients.

 

Kate Hudson has been overseeing the production, marketing, and customer service strategies of the firm. She is also the face of the company and has been ensuring that its activewear products make women feel comfortable. The company utilizes a technique that is known as reverse showrooming to increase sales in its brick-and-mortar stores. The enterprise has established over 30 stores in various regions of the United States.

Black Friday week is still going strong! Shop the sale in stores and online. (Link in bio)

A photo posted by @fabletics on

The Bumpy Road of Lacey and Larkin Frontera Fund Yet Seamlessly Absorbs the Turbulence

The Lacey and Larkin Frontera Fund was co-founded by Michael Lacey and Jim Larkin to help the Hispanic community address issues of Civil, Human and migrant rights in the American state of Arizona. In addition to the advocacy of rights, the fund additionally champions for speech freedom and public participation for all parties. Read more: Jim Larkin | LinkedIn

Although the fund operates across Arizona, it has a huge presence on the La linea fronteriza; the Mexican Border. Its core values are achieved through community education and awareness program – enlightening the public of border rules, laws, and restrictions.

In collaboration with the program are other non-profit organizations at the border such as the Border Angels. Although founded independent of each other their mission and visions seem to tangle.

Border Angeles is Enrique Morones creation based in San Diego. Its operational line is in enforcing migrant rights and immigration reforms along with the minimization and eradication of immigrant deaths and suffering.

As the two organizations match operations, the Hispanic community is the main area of interest benefit.

The Lacey and Larkin Frontera Fund has been able to educate, enlighten, foster peaceful co-existence at the border, review immigration policies and by extension, their outreach programs have boosted living standards. Apparently, the US – Mexican border has the most favorable policing.

About Lacey and Larkin Frontera Fund

There is a harsh reality behind the birth of Lacey and Larkin Frontera Fund. First forward, Michael Lacey and Jim Larkin are the founders who are close confidants and journalists.

Affiliated with Village Voice Media at the time they produced and advertised a release which was doomed unethical by Sheriff Joe Arpaio of Maricopa County. As a result, therefore, they were arrested, detained and charged, but this was short-lived since the public pushed for their successful release.

Law suit nonetheless proceeded on, and it was discovered the arrest was unlawful. A settlement of $3.75 million helped launch the foundation. Today it has been able to command a huge following and fight for the humanity of not only the Hispanic community but for all.

Affirmatively, it has prevented violation, abuses, and racism altogether. The media now has the freedom to air out issues without fear of prosecution. The fund is based in Phoenix, Arizona.

Learn more about Jim Larkin Michael Lacey:

https://about.me/jim_larkin
https://twitter.com/JimLarkin_